Built on five decades of research · Third-party tested · Made in the USA
For Longevity Clinics & Functional Medicine Practices

A novel intervention your patients
aren't already taking.

A different mechanism — immune-regulatory, not the HPA axis. A measurable biomarker. A two-week onset, measured in a 60-person randomized, placebo-controlled trial. Give your practice something new to offer — and something you can verify with bloodwork.

Request a wholesale account → See the clinical data Request samples

Every clinic recommends ashwagandha.
This is what comes next.

New mechanism
Immune-regulatory pathway — not HPA axis, not cortisol, not NMDA. A category your patients haven't seen.
Real RCT
60-person, randomized, double-blind, placebo-controlled, IRB-approved. Registered NCT07604038. Not an open-label pilot.
Measurable
hs-CRP — a biomarker you already test. Recommend, retest at 8 weeks, show the patient a number.

The trial data,
at practitioner resolution.

Study design: Randomized, double-blind, placebo-controlled (parallel). N=60. 8-week intervention, 1 mg/day. Population: healthy adults, ages 18–65. Sponsor: Kioga Inc. with the University of Colorado Boulder. Registered NCT07604038.

Active ingredient: NeuroAlly™ (KGA-10™), a heat-killed postbiotic of Mycolicibacterium petrae. 1 mg/day oral capsule.

Primary endpoints:

  • hs-CRP (week 8): 25% reduction vs. placebo (p<0.01); improvement also significant at Week 4 (p<0.05).
  • Safety & tolerability (GASE-P): no serious adverse events; well-tolerated across all participants.

Secondary endpoints:

  • Perceived stress (PSS-10): significant improvement vs. placebo by Week 2 (p<0.05), sustained through Week 8 (p<0.01); 94% responder rate by Week 2.
  • General wellbeing (SF-36): 77% reported improved emotional wellbeing and 65% improved energy by Week 8.
  • Sleep quality (PSQI): assessed across the 8-week intervention.

Mechanism category (academic literature): The published M. vaccae literature (Stanford and colleagues at UCL; Lowry and colleagues at CU Boulder) describes the organism as engaging immune-regulatory pathways, distinct from the hormonal (HPA/cortisol) or neurological (NMDA) pathways targeted by adaptogens and nootropics. This positions KGA-10™ in a novel mechanistic category by lineage. The supporting literature is preclinical and animal-model; the clinical evidence on īther's product effects rests on the 2026 RCT of NeuroAlly™.

Key differentiators vs. comparators:

  • KSM-66 ashwagandha: HPA axis mechanism, 6–8 week onset, studied primarily in stressed/clinical populations.
  • Magnesium L-threonate (Magtein): NMDA receptor mechanism, 12-week onset.
  • NeuroAlly™ (KGA-10™): Immune-regulatory category by lineage; 2-week onset measured in the trial; studied in healthy adults rather than stressed/clinical populations.
Competitive comparison
KSM-66 · HPA axis 6–8 wk onset
Magtein · NMDA 12 wk onset
NeuroAlly™ · Immune 2 wk onset
hs-CRP testing protocol
Step 1 Baseline hs-CRP (standard panel)
Step 2 Begin īther — 1 capsule daily
Step 3 Retest hs-CRP at 8-week follow-up
Step 4 Compare — trial showed 25% reduction vs. placebo
A verifiable outcome loop. Test → intervene → retest → show the patient.

Data from a 60-person randomized, double-blind, placebo-controlled clinical trial in healthy adults, 2026 (NCT07604038). Full topline available on request; peer-reviewed publication pending.

What practitioner partners receive.

Wholesale pricing
40–50% below retail. Dispense directly at full margin, or refer patients to order through ither.com with a practitioner referral margin.
Clinical materials
Practitioner education deck, patient handout (take-home one-pager), dosing protocol, and hs-CRP testing guide. All regulatory-reviewed.
Sample program
Complimentary 30-day supply for you to trial personally before recommending to patients. We want you to experience it first.
Practitioner portal
Dedicated login with wholesale ordering, reorder tracking, clinical data downloads, and patient education PDFs.
Ongoing updates
Quarterly clinical updates as new trial data becomes available — including 2026 dose-finding trial results (sleep, exercise motivation, expanded immune panel).
No minimums
Start with a case of 12 bottles. Reorder when you're ready. No contracts, no commitments, no shelf-space requirements.

Two ways to offer īther
in your practice.

Option A — Dispense
Buy wholesale, sell at retail
Purchase īther at wholesale pricing. Stock in your dispensary. Sell to patients at retail or your preferred markup. You control the patient experience and retain the full margin.
Option B — Refer
Recommend, we fulfill
Recommend īther to patients using your unique practitioner link. Patients order directly from ither.com. You earn a referral margin on every order. No inventory, no fulfillment, no risk.

Request a wholesale account
or complimentary samples.

We review practitioner applications within 48 hours. Qualified clinics receive wholesale access and a complimentary 30-day personal supply.

Practitioner Application

We respond within 48 hours. No spam. No sales calls.